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Ann Thorac Surg 2004;77:463
© 2004 The Society of Thoracic Surgeons

Invited commentary

Department of Cardiac Surgery, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA

e-mail: pedro.delnido@tch.harvard.edu
e-mail: ingeborg.friehs@tch.harvard.edu

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In the present study, the authors tested the efficacy of adenoviral mediated gene transfer of VEGF₁₆₅ to a single lung pulmonary artery stenosis model in fetal lambs, with the treatment being given early postnatally. The authors' choice of a pulmonary artery stenosis model makes the present study relevant to the clinical situation of tetralogy of Fallot and severe pulmonary stenosis or atresia. Their findings indicate that central pulmonary artery growth does occur in response to VEGF treatment and may have potential therapeutic benefit for children.

In patients with pulmonary atresia and tetralogy of Fallot, the intrapulmonary arterial circulation usually fails to . . . [Full Text of this Article]