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Ann Thorac Surg 2003;76:1340-1341
© 2003 The Society of Thoracic Surgeons

Correspondence

Early ischemic preconditioning for spinal cord protection

Ioannis K. Toumpoulis, MDa

a Department of Cardiothoracic Surgery, University Hospital of Ioannina, School of Medicine, DouroutiIoannina 45110 Greece

Constantine E. Anagnostopoulos, MDb

b Department of Cardiac Surgery, St. Luke’s/Roosevelt Hospital Center at Columbia University, 45 East 89th St, New York, NY 10128, USA

e-mail: cea8@columbia.edu

The first 20% of the full text of this article appears below.

To the Editor:

We read with great interest the article by Caparrelli and associates [1]. We congratulate them on their study of diazoxide administration to reduce neurological injury in a model of spinal cord ischemia.

Theirs was a well-designed study. It consisted of six experimental groups of rabbits and compared the effect of pharmacological versus ischemic preconditioning (IPC) on spinal cord ischemic injury and the effect of systemic hypotension (isoflurane group). The histopathological analysis is of interest because the scoring system used to assess histological damage (0, frank necrosis, to 4, normal histological appearance) allowed a quantitative histological study.

Ischemic . . . [Full Text of this Article]






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