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Right arrow Transplantation - heart

Ann Thorac Surg 2003;76:339-340
© 2003 The Society of Thoracic Surgeons

Correspondence

Avoiding compliance with histocompatibility dogma using immune privileged cell xenografts

Husnain Kh. Haider, MPharm, PhDa, Yel Lei, MDb, Shujia Jiang, MDb, Peter K. Lawc, Eugene K. W. Sim, FRCSd

a Department of Cardiothoracic and Vascular Surgery, National University of Singapore, Singapore 117597, Singapore
b 10-Medical DriveNational University of Singapore, Singapore-117597, Singapore
c 1770 Moriah Woods BlvdSuite 18Cell Therapy, Inc, Memphis, TN 38117-7126 USA
d Department of Cardiac, Thoracic and Vascular Surgery, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore

e-mail: khhaider@hotmail.com
e-mail: sursinkw@nus.edu.sg

The first 20% of the full text of this article appears below.

To the Editor:

Saito and colleagues [1] wrote an interesting report that challenges the concept of immune tolerance. They injected mice bone marrow stromal cells (BMSCs) into immunocompetent rats and demonstrated engraftment and survival. The results reveal the immune privileged nature of the BMSCs. It is well known that organ and cell transplantation between different individuals of the same species is poorly tolerated without immunosuppression. Xenotransplantation is even more problematic because of rapid rejection. This recent report of successful . . . [Full Text of this Article]






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