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Ann Thorac Surg 2003;75:1732-1733
© 2003 The Society of Thoracic Surgeons

Original article: general thoracic

Invited commentary

W. Roy Smythe, MDa

a Department of Thoracic Molecular Oncology, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe BlvdHouston, TX 77030, USA

e-mail: rsmythe@mdanderson.org

The first 20% of the full text of this article appears below.

This article by Haga and colleagues evaluates the prognostic significance of Ki-67 immunohistochemistry in patients with resected early stage nonsmall cell lung carcinoma. Although many have addressed the question of prognostic significance of this protein in solid tumors, this manuscript makes the novel association of Ki-67 expression, smoking status, and prognosis.

The use of immunohistochemistry for prognostic purposes is by no means novel, but in most cases, the function and oncologic importance of the protein being evaluated is known . . . [Full Text of this Article]






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