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Ann Thorac Surg 2003;75:1549
© 2003 The Society of Thoracic Surgeons

Original article: cardiovascular

Invited commentary

William M. DeCampli, MD, PhDa

a Division of Cardiothoracic Surgery, The Children’s Hospital of Philadelphia, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA

(Email: decampli@email.chop.edu).

The first 20% of the full text of this article appears below.

Sheil and colleagues have described a method that purportedly detects coronary artery endothelial dysfunction during controlled cardiac ischemia. The technique, which involves imaging sonicated albumin microbubbles, has been previously used in adult cardiac surgery. Prior studies in the laboratory showed that these microbubbles attach to neutrophils. Their persistence in coronary arteries indicates adherence of neutrophils to the vascular endothelium, which implies endothelial injury. This paper’s contribution is to demonstrate the safety and efficacy of this technique in the clinical pediatric population.

While . . . [Full Text of this Article]






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