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Ann Thorac Surg 2003;75:483-484
© 2003 The Society of Thoracic Surgeons

Invited commentary

Jerrold H. Levy, MD

Department of Anesthesiology, Emory University Hospital, 1364 Clifton Rd, NE, Atlanta, GA 30322, USA

e-mail: jerrold_levy@emoryhealthcare.org

The first 20% of the full text of this article appears below.

Stroke is one of the most devastating complications following cardiac surgery. In 1995, we reported a prospective study in patients undergoing repeat coronary artery bypass graft surgery and noted that administration of full dose and half dose aprotinin significantly reduces the requirement for donor-blood transfusion. Although the study was not specifically designed to assess aprotinin and stroke risk, the decreased need for transfusion was associated with a decreased incidence of stroke [1]. Interestingly, this finding has been confirmed in both a retrospective analysis of aprotinin use in clinical studies [2] and in the study reported by Furmin and colleagues from Columbia [3]. Furmin and colleagues, using their recent . . . [Full Text of this Article]




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[Abstract] [Full Text] [PDF]


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