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Ann Thorac Surg 2001;72:2180-2181
© 2001 The Society of Thoracic Surgeons


Correspondence

Pharmacological spinal cord protection with magnesium during replacement of the thoracic and thoracoabdominal aorta

Loïc Lang-Lazdunski, MD, PhDa, Jean Bachet, MDa

a Department of Cardiovascular Surgery, Institut Mutualiste Montsouris, Paris, France

To the Editor

We read with great interest the recent update by Rokkas and Kouchoukos [1] of the article "Dextrorphan Inhibits the Release of Excitatory Amino Acids During Spinal Cord Ischemia." Their continuing efforts have helped all of us to better understand the pathophysiological mechanisms implicated in spinal cord ischemia related to operations on the thoracoabdominal aorta. There is now compelling evidence that excitatory amino acids are involved in both necrotic and apoptotic death of spinal neurons after transient spinal cord ischemia. Dextrorphan, like most other N-methyl-D-aspartate (NMDA) antagonists, is no longer used clinically because of intolerable side effects [1]. However, other drugs have been found to protect the brain . . . [Full Text of this Article]




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Eur J Cardiothorac SurgHome page
C. D. Etz, T. M. Homann, K. A. Plestis, N. Zhang, M. Luehr, D. J. Weisz, G. Kleinman, and R. B. Griepp
Spinal cord perfusion after extensive segmental artery sacrifice: can paraplegia be prevented?
Eur J Cardiothorac Surg, April 1, 2007; 31(4): 643 - 648.
[Abstract] [Full Text] [PDF]




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