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Ann Thorac Surg 2001;72:2180-2181
© 2001 The Society of Thoracic Surgeons
a Department of Cardiovascular Surgery, Institut Mutualiste Montsouris, Paris, France
To the Editor
We read with great interest the recent update by Rokkas and Kouchoukos [1] of the article "Dextrorphan Inhibits the Release of Excitatory Amino Acids During Spinal Cord Ischemia." Their continuing efforts have helped all of us to better understand the pathophysiological mechanisms implicated in spinal cord ischemia related to operations on the thoracoabdominal aorta. There is now compelling evidence that excitatory amino acids are involved in both necrotic and apoptotic death of spinal neurons after transient spinal cord ischemia. Dextrorphan, like most other N-methyl-D-aspartate (NMDA) antagonists, is no longer used clinically because of intolerable side effects [1]. However, other drugs have been found to protect the brain
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