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Ann Thorac Surg 2001;72:1448
© 2001 The Society of Thoracic Surgeons

Correspondence

Does adenosine have cerebro-protective effect during cardiopulmonary bypass?: Reply

Jakob Vinten-Johansen, PhDa

a Department of Surgery (Cardiothoracic), Emory University School of Medicine, 550 Peachtree St NE, Atlanta, GA 30308-2225, USA

To the Editor

In 1993, Manuel Galiñanes and colleagues [1] issued a challenge by asking whether adenosine would continue to be ignored as a cardioprotective agent. Since this challenge was issued, we [2] and a great many other laboratories have investigated the potential mechanisms by which adenosine and its analogs might protect the heart and other organs from ischemic-reperfusion injury. Adenosine is a pluripotent nucleoside that has numerous physiological effects mediated by its interaction with specific adenosine receptors. Classic among the physiological effects of adenosine is vasodilation. However, adenosine also has potent antiinflammatory effects that may be harnessed to attenuate inflammatory responses stimulated by ischemia-reperfusion and cardiopulmonary bypass, to name but a few triggers. Adenosine inhibits superoxide radical . . . [Full Text of this Article]


Related Article

Does adenosine have cerebro-protective effect during cardiopulmonary bypass?
V.R. Machiraju
Ann. Thorac. Surg. 2001 72: 1447-1448. [Extract] [Full Text] [PDF]





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