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Ann Thorac Surg 2001;72:1447-1448
© 2001 The Society of Thoracic Surgeons

Correspondence

Does adenosine have cerebro-protective effect during cardiopulmonary bypass?

V.R. Machiraju, MDa

a Division of Cardiovascular Surgery, University of Pittsburgh Medical Center, Shadyside Hospital, 5200 Centre Ave, Suite 216, Pittsburgh, PA 15232, USA

To the Editor

Myocardial arrest is achieved during standard cardiac surgical procedures by administering potassium cardioplegic solution. This causes depolarized myocardial arrest. While this is very effective, depolarization at the cell membrane leads to ionic exchange, increase in intracellular calcium, and depletion of energy substrates. To minimize these adverse effects, polarized or hyperpolarized arrests are being investigated and the common chemical agent that has been examined is adenosine. Adenosine is an autacoid produced by the myocytes and has an effect on various receptors of the cell . . . [Full Text of this Article]


Related Article

Does adenosine have cerebro-protective effect during cardiopulmonary bypass?: Reply
Jakob Vinten-Johansen
Ann. Thorac. Surg. 2001 72: 1448. [Extract] [Full Text] [PDF]





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