ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
John A. Kern
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kern, J. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Kern, J. A.
Related Collections
Right arrow Lung - basic science
Right arrowRelated Article

Ann Thorac Surg 2001;72:1171-1172
© 2001 The Society of Thoracic Surgeons

Invited commentary

John A. Kern, MDa

a TCV Surgery, University of Virginia, Lee St, Charlottesville, VA 22908, USA

e-mail: jak3r@virginia.edu

Despite significant advances in organ procurement and preservation techniques, transplanted lungs are unusually sensitive to ischemia-reperfusion injury. Severe early graft dysfunction has been reported in up to 20% of lung recipients, and this early dysfunction can lead to an increase in early and late morbidity and mortality. Although ischemia plays an important role in initiating early post-transplant lung injury, reperfusion mechanisms are equally important. Pulmonary ischemia-reperfusion (I/R) injury is a complex process involving many cell types and inflammatory biochemical mediators. The study by Sunose and colleagues has utilized a popular dog model of lung transplantation to evaluate the effect of a COX-2 inhibitor on subsequent graft function after 12 hours of ischemia and varying times of up to 4 hours of reperfusion. The hilum of the contralateral non-transplanted lung was ligated in order to evaluate the function of the transplanted organ and its ability to support the animal. The . . . [Full Text of this Article]


Related Article

Effect of a cyclooxygenase-2 inhibitor, FK3311, in a canine lung transplantation model
Yutaka Sunose, Izumi Takeyoshi, Hirofumi Tsutsumi, Susumu Ohwada, Noboru Oriuchi, Koshi Matsumoto, and Yasuo Morishita
Ann. Thorac. Surg. 2001 72: 1165-1171. [Abstract] [Full Text] [PDF]





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2001 by The Society of Thoracic Surgeons.