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Ann Thorac Surg 2001;71:1397-1398
© 2001 The Society of Thoracic Surgeons

Update

Update 2001: dextrorphan inhibits the release of excitatory amino acids during spinal cord ischemia

Chris K. Rokkas, MDa, Nicholas T. Kouchoukos, MDa

a The Heart Center, Missouri Baptist Medical Center, St. Louis, Missouri, USA

Address reprint requests to Dr Kouchoukos, The Heart Center, Missouri Baptist Medical Center, 3009 N Ballas Rd, Suite 266-C, St. Louis, MO 63131
e-mail: ntkouch@aol.com

As Originally Published in 1994: by Chris K. Rokkas, MD, Loring R. Helfrich, Jr, BS, Douglas C. Lobner, PhD, Dennis W. Choi, MD, PhD, and Nicholas T. Kouchoukos, MD. Division of Cardiothoracic Surgery, Department of Surgery, and Department of Neurology, Washington University School of Medicine, St. Louis, Missouri.

The release of excitatory amino acids, particularly glutamate, into the extracellular space plays a causal role in irreversible neuronal damage after central nervous system ischemia. Dextrorphan, a noncompetitive N-methyl-D-aspartate receptor antagonist, has been shown to provide significant protection against cerebral damage after focal ischemia. We investigated the changes in extracellular neurotransmitter amino acid concentrations using in vivo microdialysis in a swine model of spinal cord ischemia. After lumbar laminectomies were performed, all animals underwent left thoracotomy and right atrial–femoral cardiopulmonary bypass with additional aortic arch perfusion. Microdialysis probes were then inserted stereotactically into the lumbar spinal cord. The probes were perfused with artificial cerebrospinal fluid and 15-minute samples were assayed using high-performance liquid chromatography. Group 1 animals (n = 9) underwent aortic clamping distal to the left subclavian and proximal to the renal arteries for 60 minutes. Group 2 animals (n = 7) were treated with dextrorphan before application of aortic clamps, and during aortic occlusion . . . [Full Text of this Article]




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Ann. Thorac. Surg., December 1, 2001; 72(6): 2180 - 2181.
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