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Ann Thorac Surg 2001;71:1288-1289
© 2001 The Society of Thoracic Surgeons

Invited commentary

^a Department of Thoracic and Cardiovascular Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390–8879, USA

e-mail: jessen@email.swmed.edu

Potassium-based cardioplegic solutions have long been used by surgeons to reduce the damaging effects of ischemia. The basic premise has been that depolarized arrest reduces cardiac work and myocardial energy demands, thereby increasing ischemic tolerance. This manuscript by Toyoda and colleagues provides new data that suggests that other mechanisms may be involved. In a carefully controlled series of experiments they suggest a role for ATP-sensitive potassium (K_ATP) channels . . . [Full Text of this Article]

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Opening of mitochondrial ATP-sensitive potassium channels enhances cardioplegic protection

Yoshiya Toyoda, Sidney Levitsky, and James D. McCully
Ann. Thorac. Surg. 2001 71: 1281-1288. [Abstract] [Full Text] [PDF]