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Ann Thorac Surg 2001;71:147
© 2001 The Society of Thoracic Surgeons

Invited commentary: original article: cardiovascular

Invited commentary

Hendrick B. Barner, MDa

a Division of Cardiothoracic Surgery, Washington University School of Medicine, One Barnes-Jewish Hospital Plaza, Suite 3108 Queeny Tower, St. Louis, MO 63110, USA

e-mail: barnerh@msnotes.wustl.edu

Blood vessels react to increased flow by vasodilatation, a response to increased shear stress that is detected by the endothelial cells, which signal the smooth muscle to relax. When changes in flow persist, there is restructuring of the vessel wall, including both cellular and noncellular elements, with significant change in luminal cross-sectional area and relatively small or no change in wall thickness. The end result of this vascular remodeling is normalization of wall shear stress as detected by the endothelium. . . . [Full Text of this Article]


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