ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Alessandro Brunelli
Majed Refai
Michele Salati
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brunelli, A.
Right arrow Articles by Sabbatini, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brunelli, A.
Right arrow Articles by Sabbatini, A.
Related Collections
Right arrow Lung - cancer
Right arrowRelated Article

Ann Thorac Surg 2007;83:1134-1139
© 2007 The Society of Thoracic Surgeons

Original Articles: General Thoracic

Predicted Versus Observed FEV1 and DLCO After Major Lung Resection: A Prospective Evaluation at Different Postoperative Periods

Alessandro Brunelli, MD*, Majed Refai, MD, Michele Salati, MD, Francesco Xiumé, MD, Armando Sabbatini, MD

Division of Thoracic Surgery, "Umberto I" Regional Hospital, Ancona, Italy

Accepted for publication November 20, 2006.

* Address correspondence to Dr Brunelli, Via S. Margherita 23, Ancona 60129, Italy (Email: alexit_2000{at}yahoo.com).

Background: The objective of this study was to prospectively assess the agreement between predicted and observed postoperative values of forced expiratory volume in 1 second (FEV1) and carbon monoxide lung diffusion capacity (DLCO) after major lung resection.

Methods: Two hundred consecutive patients undergoing lobectomy or pneumonectomy for lung cancer in a single center were prospectively evaluated with complete preoperative and repeated postoperative measurements of FEV1 and DLCO. Predicted postoperative (ppo) values were compared with the observed postoperative values. The precision of ppoFEV1 and ppoDLCO at 3 months was subsequently evaluated by plotting the cumulative predicted postoperative values against the observed ones.

Results: After lobectomy, observed values were 11% lower at discharge (p < 0.0001), and 6% higher at 3 months (p < 0.0001), compared with ppoFEV1. No differences were noted at 1 month. Observed DLCO values were 12% lower than predicted at discharge (p < 0.0001) and 10% higher than predicted at 3 months (p < 0.0001), without differences noted at 1 month. After pneumonectomy, no differences were noted between predicted and observed values of FEV1 at every evaluation time, and of DLCO at discharge and 1 month. However, the observed DLCO value was 17% higher than predicted at 3 months (p = 0.002). Plots of predicted and observed postoperative values at 3 months showed that ppoFEV1 predicted worse at lower levels of ppoFEV1, and ppoDLCO was constantly lower than the observed values at every ppoDLCO levels.

Conclusions: Given the imprecision of the prediction of postoperative function, particularly of gas exchange determinants and after pneumonectomy, and at low ppoFEV1 levels, the use of ppoFEV1 and ppoDLCO for risk stratification needs to be reconsidered.


Related Article

Invited commentary
Simon Jordan, Michael Polkey, and Peter Goldstraw
Ann. Thorac. Surg. 2007 83: 1139. [Extract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
H. K. Kim, D. Yoo, H. K. Sung, H. J. Lee, and Y. H. Choi
Vibration Response Imaging in Prediction of Pulmonary Function After Pulmonary Resection
Ann. Thorac. Surg., November 1, 2012; 94(5): 1680 - 1686.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
S. Welter, D. Cheufou, C. Ketscher, K. Darwiche, F. Maletzki, and G. Stamatis
Risk factors for impaired lung function after pulmonary metastasectomy: a prospective observational study of 117 cases
Eur J Cardiothorac Surg, August 1, 2012; 42(2): e22 - e27.
[Abstract] [Full Text] [PDF]

Home page
 Cleveland Clinic Journal of MedicineHome page
P. MAZZONE
Preoperative evaluation of the lung resection candidate
Cleveland Clinic Journal of Medicine, May 1, 2012; 79(e-Suppl_1): e-S17 - e-S22.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. Ueda, T. Tanaka, M. Hayashi, N. Tanaka, T.-S. Li, and K. Hamano
Clinical Ramifications of Bronchial Kink After Upper Lobectomy
Ann. Thorac. Surg., January 1, 2012; 93(1): 259 - 265.
[Abstract] [Full Text] [PDF]

Home page
 Respir CareHome page
F. Comce, Z. Bingol, E. Kiyan, S. Tanju, A. Toker, P. Cagatay, and T. Ece
Vibration-Response Imaging Versus Quantitative Perfusion Scintigraphy in the Selection of Patients for Lung-Resection Surgery
Respir Care, December 1, 2011; 56(12): 1936 - 1941.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
K. Ueda, T. Tanaka, M. Hayashi, T.-S. Li, T. Kaneoka, N. Tanaka, and K. Hamano
Compensation of pulmonary function after upper lobectomy versus lower lobectomy
J. Thorac. Cardiovasc. Surg., October 1, 2011; 142(4): 762 - 767.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. Kachare, E. U. Dexter, C. Nwogu, T. L. Demmy, and S. Yendamuri
Perioperative outcomes of thoracoscopic anatomic resections in patients with limited pulmonary reserve
J. Thorac. Cardiovasc. Surg., February 1, 2011; 141(2): 459 - 462.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
E. Lim, D. Baldwin, M. Beckles, J. Duffy, J. Entwisle, C. Faivre-Finn, K. Kerr, A. Macfie, J. McGuigan, S. Padley, et al.
Guidelines on the radical management of patients with lung cancer
Thorax, October 1, 2010; 65(Suppl_3): iii1 - iii27.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. J. Cerfolio, A. Talati, and A. S. Bryant
Changes in Pulmonary Function Tests After Neoadjuvant Therapy Predict Postoperative Complications
Ann. Thorac. Surg., September 1, 2009; 88(3): 930 - 936.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. J. Cerfolio and A. S. Bryant
Different Diffusing Capacity of the Lung for Carbon Monoxide as Predictors of Respiratory Morbidity
Ann. Thorac. Surg., August 1, 2009; 88(2): 405 - 411.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Brunelli, A. Charloux, C. T. Bolliger, G. Rocco, J-P. Sculier, G. Varela, M. Licker, M. K. Ferguson, C. Faivre-Finn, R. M. Huber, et al.
ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)
Eur. Respir. J., July 1, 2009; 34(1): 17 - 41.
[Abstract] [Full Text] [PDF]

Home page
 Interact CardioVasc Thorac SurgHome page
K. Kushibe, T. Kawaguchi, M. Kimura, M. Takahama, T. Tojo, and S. Taniguchi
Influence of the site of lobectomy and chronic obstructive pulmonary disease on pulmonary function: a follow-up analysis
Interact CardioVasc Thorac Surg, May 1, 2009; 8(5): 529 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
A. Brunelli, G. Varela, G. Rocco, L. Socci, N. Novoa, T. Gatani, M. Salati, and A. L. Rocca
A model to predict the immediate postoperative FEV1 following major lung resections
Eur J Cardiothorac Surg, November 1, 2007; 32(5): 783 - 786.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. W. Asaph
Invited commentary
Ann. Thorac. Surg., August 1, 2007; 84(2): 416 - 416.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. Jordan, M. Polkey, and P. Goldstraw
Invited commentary
Ann. Thorac. Surg., March 1, 2007; 83(3): 1139 - 1139.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2007 by The Society of Thoracic Surgeons.