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Ann Thorac Surg 2002;73:1035-1040
© 2002 The Society of Thoracic Surgeons

Original article: general thoracic

Results of surgical treatment of adenocarcinoma of the gastric cardia

Giovanni de Manzoni, MD*a, Corrado Pedrazzani, MDa, Felice Pasini, MDb, Alberto Di Leo, MDa, Emilia Durante, MDb, Gabriele Castaldini, MDa, Claudio Cordiano, MDa

a First Division of General Surgery, University of Verona, Verona, Italy
b Division of Medical Oncology, University of Verona, Verona, Italy

Accepted for publication November 19, 2001.

* Address reprint requests to Dr de Manzoni, 1a Chirurgia Clinicizzata, Ospedale di Borgo Trento, Piazzale Stefani 1, 37126 Verona, Italia, Italy
e-mail: chirurgia.urgenza{at}univr.it

Background. Comparison among different studies regarding adenocarcinoma of the cardia has been difficult since the Siewert classification was introduced. This study analyzed the experience of a single institution in the treatment of gastric cardia cancer with the aim of assessing principal prognostic factors and long-term outcome.

Methods. The results of 96 patients who underwent resection with curative intent for gastric cardia cancer at the First Division of General Surgery, University of Verona, from January 1988 to February 2000, were analyzed statistically with special reference to Siewert type.

Results. Despite a high number of curative resections (85.4%), the 5-year survival rate was poor (24%) for all Siewert types (p = 0.8), and for early tumors (51%) also. Chance of cure was limited to pN0 and pN1 patients. Multivariate analysis showed that microscopic or macroscopic residual tumor and pN-positive categories had a significantly higher risk of death (risk ratio, 2.18 and 2.68, respectively) and the pN2 and pN3 category had the most negative prognostic factor (risk ratio, 7.6).

Conclusions. The long-term prognosis for gastric cardia cancer remains poor and is independent of Siewert type, with cure limited to pN0 and pN1 patients.


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Ann. Thorac. Surg. 2002 73: 1040. [Extract] [Full Text] [PDF]



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