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Ann Thorac Surg 2001;72:1165-1171
© 2001 The Society of Thoracic Surgeons

Original article: general thoracic

Effect of a cyclooxygenase-2 inhibitor, FK3311, in a canine lung transplantation model

Yutaka Sunose, MDa, Izumi Takeyoshi, MDa, Hirofumi Tsutsumi, MDa, Susumu Ohwada, MDa, Noboru Oriuchi, MDb, Koshi Matsumoto, MDc, Yasuo Morishita, MDa

a Second Department of Surgery, Gunma University School of Medicine, Gunma, Japan
b Department of Nuclear Medicine, Gunma University School of Medicine, Gunma, Japan
c Department of Pathology, Nippon Medical School, Kanagawa, Japan

Accepted for publication May 16, 2001.

Address reprint requests to Dr Takeyoshi, Second Department of Surgery, Gunma University School of Medicine, 3-39-15 Showa-Machi, Maebashi, Gunma 371-8511, Japan
e-mail: takeyosi{at}showa.gunma-u.ac.jp

Background. In the process of ischemia–reperfusion, inflammatory cytokines and arachidonic acid metabolites are released and followed by tissue damage. FK3311 (FK) is a selective cyclooxygenase-2 inhibitor that inhibits conversion of arachidonic acid into thromboxane A2 or prostaglandin I2. We investigated the effects of FK in canine lung transplantation.

Methods. FK3311 was administered in the FK group, and vehicle was injected in the control group. The left lung was orthotopically transplanted after 12-hour preservation in Euro-Collins solution. After reperfusion, the right pulmonary artery and bronchus were ligated, and the animals were observed. Pulmonary gas exchange and hemodynamics were measured, histopathologic damages were investigated, and technetium-99m-labeled albumin scintigraphy was performed. The serum prostanoid levels were also measured.

Results. In the FK group, pulmonary gas exchange and hemodynamics were significantly (p < 0.05) better, histologic damage and neutrophil infiltration was reduced, and technetium-99m-albumin accumulation was considerably suppressed. Also, thromboxane B2 was significantly (p < 0.05) lower, but 6-keto-prostaglandin F1{alpha} was not significantly reduced.

Conclusions. FK3311 generates protective effects on lung transplantation by a marked inhibition of thromboxane A2.


Related Article

Invited commentary
John A. Kern
Ann. Thorac. Surg. 2001 72: 1171-1172. [Extract] [Full Text] [PDF]





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