ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Christian Sebening
Christian Friedrich Vahl
Siegfried Hagl
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Szabó, G.
Right arrow Articles by Hagl, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Szabó, G.
Right arrow Articles by Hagl, S.
Related Collections
Right arrowRelated Article

Ann Thorac Surg 1999;67:18-25
© 1999 The Society of Thoracic Surgeons

Original Articles

Modulation of coronary perfusion pressure can reverse cardiac dysfunction after brain death

Gábor Szabó, MDa, Thilo Hackert, MSa, Christian Sebening, MDa, Christian Friedrich Vahl, MDa, Siegfried Hagl, MDa

a Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany

Address reprint requests to Dr Szabó, Department of Cardiac Surgery, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
e-mail: dzsi{at}hotmail.com

Presented at the Thirty-fourth Annual Meeting of The Society of Thoracic Surgeons, New Orleans, LA, Jan 26–28, 1998.

Background. Brain death results in a rapid decline in left ventricular function, which has clinical relevance for organ transplantation. The aim of the present study was to investigate coronary perfusion changes during brain death and their role in cardiac dysfunction.

Methods. In an in situ isolated canine heart model, brain death was induced by inflation of a subdural balloon catheter. The heart was perfused separately with the animal’s own blood by a pressure-controlled roller pump that was coupled to the measured aortic pressure. Myocardial contractility was estimated by the slope of the end-systolic pressure–volume relation.

Results. Induction of brain death resulted in a transient hyperdynamic response, followed by a significant decrease in systemic vascular resistance, coronary blood flow, and the end-systolic pressure–volume relation (p < 0.05). However, if coronary perfusion pressure was decoupled from aortic pressure and elevated to pre–brain death levels, coronary blood flow and the end-systolic pressure–volume relation were also restored to baseline levels.

Conclusion. Severe impairment of coronary blood flow may contribute to decreased contractility after brain death that can be reversed by modulation of coronary perfusion pressure.


Related Article

Discussion
Ann. Thorac. Surg. 1999 67: 25-26. [Extract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
 Eur. J. Cardiothorac. Surg.Home page
Y. Oishi, Y. Nishimura, K.-i. Imasaka, N. Kajihara, S. Morita, M. Masuda, and H. Yasui
Impairment of coronary flow reserve and left ventricular function in the brain-dead canine heart
Eur. J. Cardiothorac. Surg., September 1, 2003; 24(3): 404 - 410.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. Seguin, Y. Devaux, S. Grosjean, E. M. Siaghy, P. Mairose, F. Zannad, N. de Talance, D. Ungureanu-Longrois, and P. M. Mertes
Evidence of Functional Myocardial Ischemia Associated With Myocardial Dysfunction in Brain-Dead Pigs
Circulation, September 18, 2001; 104(90001): I-197 - 201.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
G. Szabo, T. Hackert, V. Buhmann, A. Graf, C. Sebening, C.F. Vahl, and S. Hagl
Downregulation of myocardial contractility via intact ventriculo-arterial coupling in the brain dead organ donor
Eur. J. Cardiothorac. Surg., July 1, 2001; 20(1): 170 - 176.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1999 by The Society of Thoracic Surgeons.