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Ann Thorac Surg 2012;94:311-316. doi:10.1016/j.athoracsur.2012.03.025
© 2012 The Society of Thoracic Surgeons
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Right arrow Lung - cancer

Review

A Systematic Review of Pulmonary Embolism in Patients With Lung Cancer

Rafael D. Malgor, MD, RPVIa,*, Thomas V. Bilfinger, MD, ScDb, Nicos Labropoulos, PhD, DICa

a Division of Vascular Surgery, Department of Surgery, Stony Brook University Medical Center, Stony Brook, New York
b Division of Cardiothoracic Surgery, Department of Surgery, Stony Brook University Medical Center, Stony Brook, New York

* Address correspondence to Dr Malgor, Division of Vascular Surgery, Department of Surgery, HSC T19 Rm 90, Stony Brook University Medical Center, Stony Brook, NY 11794-8191 (Email: rafael.malgor{at}sbumed.org).

Pulmonary embolism (PE) is increasingly recognized as causing significant morbidity and mortality in modern societies; however, little is known about PE in patients with lung cancer. We systematically reviewed Medline, Web of Science, and the Cochrane Library databases and selected 26 studies, including 2 randomized controlled trials, and 4 prospective, 18 retrospective cohort, and 2 case-control studies. Overall incidence of PE was 3.6%. Pulmonary embolism abbreviated survival in 2 studies when the diagnosis was synchronous with lung cancer. Venous thromboembolism prophylaxis, treatment, and surveillance are inconsistently reported. Clinical outcome data pertaining to this topic are limited and of overall poor methodologic quality.






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