HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Luo, K.-J. Articles by Hu, Y. Search for Related Content PubMed PubMed Citation Articles by Luo, K.-J. Articles by Hu, Y. Related Collections Esophagus - cancer Related Article

---

Original Articles: General Thoracic

Prognostic Relevance of Id-1 Expression in Patients With Resectable Esophageal Squamous Cell Carcinoma

^a State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, People's Republic of China
^b Department of Thoracic Oncology, Cancer Center, Sun Yat-Sen University, Guangzhou, People's Republic of China
^c Department of Pathology, Cancer Center, Sun Yat-Sen University, Guangzhou, People's Republic of China

Accepted for publication January 31, 2012.

^_* Address correspondence to Dr Hu, Department of Thoracic Oncology, Cancer Center, Sun Yat-Sen University, 651 Dong Feng Rd E, Guangzhou 510060, People's Republic of China (Email: huyi{at}sysucc.org.cn).

Background: Inhibitor of differentiation or DNA binding 1 (Id-1) is a transcriptional regulator that is associated with enhanced malignant potential and unfavorable survival in many cancers. However, its role and clinical significance in resectable esophageal squamous cell carcinoma (ESCC) has not been elucidated adequately. The purpose of this study was to explore the pattern of Id-1 expression and analyze its correlation with clinical outcomes of patients with resectable ESCC.

Methods: Primary tumors from 407 surgically resected ESCC specimens assembled on tissue microarrays were evaluated with immunohistochemical analysis for Id-1. The effect of Id-1 expression on survival outcome was analyzed by the Kaplan-Meier method.

Results: The expression of Id-1 correlated closely with pT category (p < 0.001), pathologic staging (p < 0.001), and pN category (p < 0.001). The sensitivity, specificity, and accuracy of predicting lymph node metastasis by Id-1 expression were 93.3%, 94.7%, and 94.1%, respectively. Disease-specific survival was significantly favorable in patients with low-level Id-1 expression (p < 0.001). Overexpression of Id-1 was also effective to predict unfavorable survival in subgroups of patients with poor differentiation (p < 0.001) or with advanced T staging (p < 0.001). Multivariate analysis showed that the level of Id-1 expression was an independent prognostic factor in ESCC (p < 0.001; relative risk, 1.578).

Conclusions: Expression of Id-1 can be used as a complement for predicting lymph node metastasis in pretreatment workup. High level of Id-1 expression suggested unfavorable prognosis for patients with resectable ESCC.

Related Article

Invited Commentary

Kenneth A. Kesler
Ann. Thorac. Surg. 2012 93: 1688-1689. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				W. Fang Invited Commentary Ann. Thorac. Surg., January 1, 2013; 95(1): 290 - 291. [Full Text] [PDF]

				K. A. Kesler Invited Commentary Ann. Thorac. Surg., May 1, 2012; 93(5): 1688 - 1689. [Full Text] [PDF]