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Ann Thorac Surg 2010;90:e38-e39. doi:10.1016/j.athoracsur.2010.06.042
© 2010 The Society of Thoracic Surgeons
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Anthony P.C. Yim
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Right arrow Lung - cancer

Case Reports

Synchronous Primary Lung Cancer and Epidermal Growth Factor Receptor Mutation

Edmond S.K. Ma, MDa,*, Paul N.M. Cheng, MDb, Chris L.P. Wong, PhDa, Anthony P.C. Yim, MDc

a Department of Pathology, Happy Valley, Hong Kong Sanatorium & Hospital, Hong Kong
b Division of Medical Oncology, Happy Valley, Hong Kong Sanatorium & Hospital, Hong Kong
c Minimally Invasive Center, Union Hospital, Shatin, Hong Kong

Accepted for publication June 7, 2010.

* Address correspondence to Dr Ma, Department of Pathology, 1/F Li Shu Fan Block, Hong Kong Sanatorium & Hospital, 2 Village Rd, Happy Valley, Hong Kong (Email: eskma{at}hksh.com).

We describe a 75-year-old Chinese man who presented with three separate tumors in three different lobes of the lung, without evidence of mediastinal or systemic involvement. All three tumors were surgically resected by minimal invasive approach. Based on a differing epidermal growth factor receptor (EGFR) mutation status, the tumors were characterized as synchronous triple primary rather than intrapulmonary metastases. This report highlights the clinical usefulness of molecular cancer biomarkers to determine prognosis and to guide management decision in multiple lung tumors.




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