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a Robert Wood Johnson Medical School, New Brunswick, New Jersey
b Cleveland Clinic, Cleveland, Ohio
c Lankenau Medical Science Hospital, Wynnewood, Pennsylvania
d University of California San Diego, San Diego, California
e Columbia University Medical Center, New York, New York
f University of Pennsylvania, Philadelphia, Pennsylvania
g Abiomed, Inc, Danvers, Massachusetts
Accepted for publication March 22, 2010.
* Address correspondence to Dr Anderson, Robert Wood Johnson Medical School, 51 French St, New Brunswick, NJ 08903 (Email: andersm2{at}umdnj.edu).
Background: The mortality rate of patients experiencing acute myocardial infarction (AMI) complicated by cardiogenic shock remains high. After conventional therapies have failed, ventricular assist devices (VADs) have been used to bridge patients to recovery or transplantation.
Methods: A voluntary US registry was established to track all patients implanted with the AB5000 VAD. We report the results of the first 100 patients in the registry with the indication of AMI cardiogenic shock. Data were retrospectively reviewed for demographics, preimplant condition, surgical techniques, and outcomes. Survival was assessed at 30 days after VAD explant or at discharge. Myocardial recovery (subset of survival) was defined as satisfactory unassisted native cardiac function for 30 days after VAD explant or at discharge.
Results: Forty patients (40%) survived to 30 days after VAD explant or discharge of the first 100 patients. Of the survivors, 63% (n = 25) experienced myocardial recovery. Patients who recovered required an average of 25 ± 22 days of VAD support. The estimated survival after explant for the recovery patients at 2 years after VAD explant was 78%.
Conclusions: Results from this nationwide registry suggest that VADs can restore normal hemodynamics and support recovery of native cardiac function in the majority of survivors when conventional therapies fail. However, a longer duration of support than previously recognized may be required. In the absence of clinical guidelines, early aggressive use of VAD support in AMI complicated by cardiogenic shock may improve outcomes, and recovery of native cardiac function should always be the primary goal.
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