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Supplement: 2nd International Bi-Annual Minimally Invasive Thoracic Surgery Summit

Cancer Stem Cells in Lung Tumorigenesis

^a Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts
^b Department of Surgery, University of California San Francisco Cancer Center, San Francisco, California

^_* Address correspondence to Dr Kratz, Department of Surgery, UCSF Helen Diller Family Comprehensive Cancer Center, 2340 Sutter St, Rm N261, University of California-San Francisco, San Francisco, CA 94115-1724 (Email: johannes.kratz{at}ucsfmedctr.org).

Presented at the 2^nd International Bi-Annual Minimally Invasive Thoracic Surgery Summit, Boston, MA, October 9–10, 2009.

Although stem cells were discovered more than 50 years ago, we have only recently begun to understand their potential importance in cancer biology. Recent advances in our ability to describe, isolate, and study lung stem cell populations has led to a growing recognition of the central importance cells with stem cell-like properties may have in lung tumorigenesis. This article reviews the major studies supporting the existence and importance of cancer stem cells in lung tumorigenesis. Continued research in the field of lung cancer stem cell biology is vital, as ongoing efforts promise to yield new prognostic and therapeutic targets.