HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Cristina Firanescu Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by van Straten, A. H.M. Articles by van Zundert, A. A.J. Search for Related Content PubMed PubMed Citation Articles by van Straten, A. H.M. Articles by van Zundert, A. A.J. Related Collections Coronary disease

---

Original Articles: Adult Cardiac

Peripheral Vascular Disease as a Predictor of Survival After Coronary Artery Bypass Grafting: Comparison With a Matched General Population

^a Department of Cardiothoracic Surgery, Catharina Hospital, Eindhoven, The Netherlands
^b Department of Education and Research, Catharina Hospital, Eindhoven, The Netherlands
^c Department of Anesthesiology, Catharina Hospital, Eindhoven, The Netherlands
^d Department of Medical Psychology, Centre of Research on Psychology in Somatic Diseases, Tilburg University, Tilburg, The Netherlands
^e Brabant Medical School, Eindhoven, The Netherlands
^f University Hospital Ghent, Ghent, Belgium

Accepted for publication November 12, 2009.

^_* Address correspondence to Dr Soliman Hamad, Department of Cardiothoracic Surgery, Catharina Hospital, Michelangelolaan 2, Postbus 1350, 5602 ZA Eindhoven, The Netherlands (Email: aasmsn{at}cze.nl).

Background: The European system for cardiac operative risk evaluation, the most popular European scoring system in cardiac surgery, uses the extracardiac arteriopathy as a risk factor for early mortality. We studied the effect of peripheral vascular disease (PVD) on early and late mortality in a large group of patients undergoing isolated coronary artery bypass surgery (CABG) surgery.

Methods: During a ten-year period (January 1998 through December 2007) 10,626 patients underwent isolated CABG in our hospital. The primary endpoints of this study were early and late all-cause mortality. For each year of the study period, general population cohorts were matched with the patient groups for age and gender (expected survival).

Results: Out of 10,504 patients included in the analysis, 1,222 (11.63%) patients had PVD. The PVD was identified as an independent risk factor for late mortality (death at any time after hospital discharge) (hazard ratio of 1.67 [1.43 to 1.95], p < 0.0001), but not for early mortality (death within 30 days or before discharge) (hazard ratio of 1.06 [0.70 to 1.60], p = 0.776). Patients without PVD had a better survival than patients with PVD (log-rank p < 0.0001) and even a better survival compared to the normal Dutch population survival (p value < 0.002). The PVD patients had a worse than expected survival (log-rank p < 0.0001).

Conclusions: Peripheral vascular disease is an independent risk factor only for late mortality but not for early mortality. Compared with age-matched and sex-matched cohorts from the general Dutch population, the ten-year survival of patients with peripheral vascular disease was worse; whereas the survival of patients with no peripheral vascular disease was better.

This article has been cited by other articles:

				O. Ozeke, M. Gungor, and C. Ozer Is Remote Ischemic Preconditioning Triggered by Intermittent Claudication Secondary to Peripheral Arterial Disease Responsible for Preventing Early Mortality After Coronary Artery Bypass Surgery? Ann. Thorac. Surg., January 1, 2011; 91(1): 333 - 334. [Full Text] [PDF]