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Case Reports

Intralobar Pulmonary Sequestration Associated With Marked Elevation of Serum Carbohydrate Antigen 19-9

^a Department of Surgery, Oami Hospital, Oamishirasato, Japan
^b Department of Respiratory Surgery, Kameda General Hospital, Kamogawa, Japan
^c Department of Clinical Pathology, Chiba Foundation for Health Promotion and Disease Prevention, Chiba, Japan

Accepted for publication May 5, 2009.

^_* Address correspondence to Dr Ambiru, Department of Surgery, Oami Hospital, 884-1 Tomita, Oamishirasato, 299-3221, Japan (Email: ambiru-s{at}umin.ac.jp).

This report describes a 62-year-old man who experienced elevated serum carbohydrate antigen 19-9 (CA19-9) levels (>500 U/mL) for 4 years, and was finally diagnosed with right intralobar pulmonary sequestration. Surgery confirmed the presence an aberrant artery arising from the descending thoracic aorta and entering the right lower lobe basal segment. Immunohistochemistry demonstrated markedly positive staining of CA19-9 in the ciliated cylindrical epithelia, alveoli, and mucus in the cysts. After pulmonary resection, CA19-9 levels decreased to within a normal range. Therefore, the cause of the elevated serum CA19-9 levels in this case was almost certainly due to intralobar pulmonary sequestration.