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Ann Thorac Surg 2009;88:1333-1335. doi:10.1016/j.athoracsur.2009.02.075
© 2009 The Society of Thoracic Surgeons
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Akira Sezai
Mitsumasa Hata
Satoshi Unosawa
Kazutomo Minami
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Right arrow Cardiac - pharmacology

Case Reports

New Treatment With Human Atrial Natriuretic Peptide for Postoperative Myonephropathic Metabolic Syndrome

Akira Sezai, MD, PhD*, Mitsumasa Hata, MD, PhD, Tesuya Niino, MD, PhD, Isamu Yoshitake, MD, PhD, Satoshi Unosawa, MD, PhD, Hisaki Umezawa, MD, PhD, Kazutomo Minami, MD, PhD

The Department of Cardiovascular Surgery, Nihon University School of Medicine, Tokyo, Japan

Accepted for publication February 16, 2009.

* Address correspondence to Dr Sezai, The Department of Cardiovascular Surgery, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi Itabashi-ku, Tokyo, 173-8610, Japan (Email: asezai{at}med.nihon-u.ac.jp).

A 49-year-old man had sudden chest pain and paralysis of the lower right limb. An acute aortic dissection was diagnosed in a computed tomography scan and the patient underwent an emergency operation. After the operation, myonephropathic metabolic syndrome developed, and human atrial natriuretic peptide was administered for 11 days until the volume of daily urine output reached at least 10,000 mL, which would facilitate limb salvage and the preservation of life without hemodialysis. This report documents that postoperative myonephropathic metabolic syndrome improved due to the strong diuretic action of human atrial natriuretic peptide without hemodialysis.






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