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Ann Thorac Surg 2009;88:1036-1043. doi:10.1016/j.athoracsur.2009.02.093
© 2009 The Society of Thoracic Surgeons
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Arthur C. Coffey
John W. Fehrenbacher
Daniel J. Beckman
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Review

Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart

Aaron M. Abarbanell, MDb, Arthur C. Coffey, MDa, John W. Fehrenbacher, MDa, Daniel J. Beckman, MDa, Jeremy L. Herrmann, MDb, Brent Weil, MDb, Daniel R. Meldrum, MDa,b,c,d,*

a Clarian Cardiovascular Surgery, Methodist Hospital, Indianapolis, Indiana
b Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana
c Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana
d Center for Immunobiology, Indiana University School of Medicine, Indianapolis, Indiana

* Address correspondence to Dr Meldrum, 2017 Van Nuys Medical Science Building, 635 Barnhill Dr, Indianapolis, IN 46202 (Email: dmeldrum{at}iupui.edu).

Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.






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