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Case Reports

Successful Factor XIII Administration for Persistent Chylothorax After Lung Transplantation for Lymphangioleiomyomatosis

^a Department of General Thoracic Surgery, Osaka University Graduate, School of Medicine, Osaka, Japan
^b Department of Cardiovascular Surgery, Osaka University Graduate, School of Medicine, Osaka, Japan

Accepted for publication January 16, 2009.

^_* Address correspondence to Dr Shigemura, Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (L5), Suita-City, Osaka, 565-0871, Japan (Email: shigemura{at}thoracic.med.osaka-u.ac.jp).

Lung transplantation has emerged as a viable treatment option for patients with end-stage lymphangioleiomyomatosis (LAM), and therapeutic outcome results reported thus far have been satisfactory. However, persisting chylothorax after transplantation for LAM remains a challenging problem, and the optimal management has not been decided. We present the case with persistent chylothorax after lung transplantation for LAM, in which the intravenous administration of a tissue repair factor (human factor XIII) resulted in complete resolution of chylous effusion without performing additional invasive treatments, leading to a successful transplant outcome.