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Ann Thorac Surg 2009;87:1981-1992. doi:10.1016/j.athoracsur.2008.12.063
© 2009 The Society of Thoracic Surgeons
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Biochemical Injury Markers and Mortality After Coronary Artery Bypass Grafting: A Systematic Review

Liisa Petäjä, MDa,*, Markku Salmenperä, MD, PhDa, Kari Pulkki, MD, PhDb, Ville Pettilä, MD, PhDa

a Department of Anesthesiology and Intensive Care Medicine of Helsinki University Central Hospital, Helsinki, Finland
b Eastern Finland Laboratory Center and University of Kuopio, Kuopio, Finland

* Address correspondence to Dr Petäjä, Department of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, PO Box 340, Helsinki, FIN-00029 HUS, Finland (Email: liisa.petaja{at}hus.fi).

The strength of the association between cardiac biomarker release and prognosis is uncertain. We performed a systematic literature search to find articles regarding these markers and death after coronary surgical interventions, and evaluated the results with meta-analytic methods. We found 23 articles concerning 29,483 patients that reported the MB fraction of creatine kinase (CK-MB) and troponin T and I. Heterogeneity of existing studies prevented the pooling of the results of troponin studies. The pooled data of the CK-MB studies suggest that after coronary artery bypass grafting, CK-MB release of more than five to eight times the upper limit of the reference range is associated with an increased risk of death during the next 40 months.




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Which Troponometric Best Predicts Midterm Outcome After Coronary Artery Bypass Graft Surgery?
Ann. Thorac. Surg., June 1, 2011; 91(6): 1860 - 1867.
[Abstract] [Full Text] [PDF]


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