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Reviews

Biochemical Injury Markers and Mortality After Coronary Artery Bypass Grafting: A Systematic Review

^a Department of Anesthesiology and Intensive Care Medicine of Helsinki University Central Hospital, Helsinki, Finland
^b Eastern Finland Laboratory Center and University of Kuopio, Kuopio, Finland

^_* Address correspondence to Dr Petäjä, Department of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, PO Box 340, Helsinki, FIN-00029 HUS, Finland (Email: liisa.petaja{at}hus.fi).

The strength of the association between cardiac biomarker release and prognosis is uncertain. We performed a systematic literature search to find articles regarding these markers and death after coronary surgical interventions, and evaluated the results with meta-analytic methods. We found 23 articles concerning 29,483 patients that reported the MB fraction of creatine kinase (CK-MB) and troponin T and I. Heterogeneity of existing studies prevented the pooling of the results of troponin studies. The pooled data of the CK-MB studies suggest that after coronary artery bypass grafting, CK-MB release of more than five to eight times the upper limit of the reference range is associated with an increased risk of death during the next 40 months.