| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
a Bristol Heart Institute, Bristol University, Bristol, United Kingdom
b Cardiac Surgery Department, S. Andrea Hospital, University of Rome "La Sapienza," Rome, Italy
Accepted for publication March 17, 2009.
* Address correspondence to Dr Caputo, Bristol Heart Institute, Bristol Royal Infirmary, Bristol, BS2 8HW, United Kingdom (Email: m.caputo{at}bristol.ac.uk).
Presented at the Poster Session of the Forty-fifth Annual Meeting of The Society of Thoracic Surgeons, San Francisco, CA, Jan 26–28, 2009.
Background: Postoperative atrial fibrillation is still a common complication in patients undergoing coronary artery bypass grafting. The aim of this study was to evaluate the effect of preoperative statin therapy on new onset of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.
Methods: Of 8,946 patients undergoing isolated coronary artery bypass grafting at the Bristol Heart Institute from April 1996 to September 2006, 6,321 (70.6%) received preoperative statins. Of these, 2,152 patients (statin group) were matched to a control group (no statin) by propensity score analysis.
Results: Preoperative characteristics, number of distal anastomoses, and the use of off -pump procedures were similar in both groups. Hospital mortality was 1.3% (56 patients) with no difference between the two groups. Postoperative atrial fibrillation was significantly higher in the statin compared with the no statin group (411, 19.5%, versus 336; 15.8% respectively; p = 0.002). In a multivariate regression analysis, age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), pulmonary disease (OR, 1.42; 95% CI, 1.12–1.82), history of paroxysmal atrial fibrillation (OR, 3; 95% CI, 2.13 to 4.19), preoperative angiotensin-converting enzyme inhibitor therapy (OR, 1.26; 95% CI, 1.07 to 1.49), ejection fraction less than 0.30 (OR, 1.71; 95% CI, 1.22 to 2.38), emergency operations (OR, 4.5; 95% CI, 2 to 10.12), and preoperative statin treatment (OR, 1.31; 95% CI, 1.11 to 1.55) were all independent predictors of postoperative atrial fibrillation.
Conclusions: Preoperative statin is associated with a significantly higher incidence of postoperative atrial fibrillation compared with no statin treatment in patients undergoing isolated coronary artery bypass grafting.
Related Article
Ann. Thorac. Surg. 2009 87: 1858.
This article has been cited by other articles:
|
|
 |
|
  I. Savelieva, N. Kakouros, A. Kourliouros, and A. J. Camm Upstream therapies for management of atrial fibrillation: review of clinical evidence and implications for European Society of Cardiology guidelines. Part I: primary prevention Europace, March 1, 2011; 13(3): 308 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kourliouros, O. Valencia, M. T. Hosseini, M. Mayr, M. Sarsam, J. Camm, and M. Jahangiri Preoperative high-dose atorvastatin for prevention of atrial fibrillation after cardiac surgery: A randomized controlled trial J. Thorac. Cardiovasc. Surg., January 1, 2011; 141(1): 244 - 248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Patel, P. Mohanty, L. Di Biase, Y. Wang, M. H. Shaheen, J. E. Sanchez, R. P. Horton, G. J. Gallinghouse, J. D. Zagrodzky, S. M. Bailey, et al. The impact of statins and renin-angiotensin-aldosterone system blockers on pulmonary vein antrum isolation outcomes in post-menopausal females Europace, March 1, 2010; 12(3): 322 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Gammie Invited Commentary Ann. Thorac. Surg., June 1, 2009; 87(6): 1858 - 1858. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
