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Ann Thorac Surg 2009;87:655-662. doi:10.1016/j.athoracsur.2008.08.003
© 2009 The Society of Thoracic Surgeons
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Review

Exploring the Association Between Elevated Body Mass Index and Barrett's Esophagus: A Systematic Review and Meta-Analysis

Paresh Kamat, MD, MPHa,c, Sijin Wen, PhDb, Jeffrey Morris, PhDb, Sharmila Anandasabapathy, MDa,*

a Division of Gastroenterology, The Mount Sinai Medical Center, New York, New York
b Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, Texas
c Department of Internal Medicine, St. Lukes Roosevelt Hospital Center, New York, New York

* Address correspondence to Dr Anandasabapathy, Division of Gastroenterology, The Mount Sinai Medical Center, Box 1069, One Gustave Levy Place, New York, NY 10029 (Email: sharmila.anandasabapathy{at}mountsinainyuhealth.org).

We performed a systematic review and meta-analysis to study the association between elevated body mass index (BMI) and Barrett's esophagus (BE). Cross-sectional, case-control and cohort studies published through February 2008 that met strict inclusion and exclusion criteria were included. Summary estimates were calculated for the association between BE and being either overweight (BMI ≥ 25 kg/m2) or obese (BMI ≥ 30 kg/m2), or both. Based on 11 studies included in this analysis, there was a statistically significant relationship between increasing BMI and BE. Further studies are needed to evaluate if the presence of reflux attenuates the strength of this relationship, and if a particular pattern of obesity is more strongly associated with BE.




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