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Ann Thorac Surg 2009;87:629-631. doi:10.1016/j.athoracsur.2008.06.040
© 2009 The Society of Thoracic Surgeons
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Bruno Reichart
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Right arrow Cardiac - pharmacology

Case Reports

Acute Profound Thrombocytopenia After Treatment With Tirofiban and Off-Pump Coronary Artery Bypass Grafting

Andres Beiras-Fernandez, MDa,*,*, Anke Kowert, MDa,*, Pascale Jiru, MDb, Marion Weis, MDb, Michael Spannagl, MDc, Bruno Reichart, MDa, Michael Schmoeckel, MDa

a Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany
b Department of Anesthesiology, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany
c Department of Transfusion Medicine, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany

Accepted for publication June 10, 2008.

* Address correspondence to Dr Beiras-Fernandez, Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, 81377, Germany (Email: andres.beiras{at}med.uni-muenchen.de).

The glycoprotein IIb/IIIa (GP IIb/IIIa) receptor antagonists prevent platelet aggregation and thrombus formation, improving outcomes of patients with acute coronary syndrome. Therapy with these agents may lead to bleeding complications and thrombocytopenia, challenging the perioperative management of patients undergoing coronary surgery. We report the successful management of an acute profound thrombocytopenia after urgent off-pump coronary surgery in a patient treated with tirofiban for unstable angina and acute coronary syndrome.




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Home page
 Ann. Thorac. Surg.Home page
F. Bizzarri and G. Frati
Acute profound thrombocytopenia after treatment with tirofiban and off-pump coronary artery bypass grafting: is there a paradox?
Ann. Thorac. Surg., September 1, 2009; 88(3): 1048 - 1048.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Beiras-Fernandez, M. Weis, and M. Schmoeckel
Reply
Ann. Thorac. Surg., September 1, 2009; 88(3): 1048 - 1048.
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