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Ann Thorac Surg 2008;86:e7-e8. doi:10.1016/j.athoracsur.2008.07.062
© 2008 The Society of Thoracic Surgeons
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Takahiro Oto
Hiroshi Date
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Right arrow Lung - transplantation

Case Reports

Sirolimus Ameliorated Post Lung Transplant Chylothorax in Lymphangioleiomyomatosis

Toshiaki Ohara, MDa, Takahiro Oto, MDa,*, Kentaro Miyoshi, MDa, Hiroyuki Tao, MDa, Masaomi Yamane, MDa, Shinichi Toyooka, MDa, Megumi Okazaki, RNa, Hiroshi Date, MDb, Yoshifumi Sano, MDa

a Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan
b Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan

Accepted for publication July 9, 2008.

* Address correspondence to Dr Oto, Department of Thoracic Surgery, Okayama University Hospital, 2-5-1, Shikata-cho, Okayama, 700-8558, Japan (Email: oto{at}md.okayama-u.ac.jp).

We report a successful case of sirolimus treatment for chylous pleural and peritoneal effusions of lymphangioleiomyomatosis after lung transplantation. A 32-year-old woman underwent living donor lung transplantation. Persistent chylous pleural and peritoneal effusions were seen postoperatively. Pleurodesis by intrathoracic injection of OK-432, minomycin, and somatostatine analog failed to control chylous effusions. However, sirolimus treatment reduced the amount of chylous drainage and improved both chylous pleural and peritoneal effusions.




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