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Original Articles: Adult Cardiac

Prevention of Sternal Dehiscence and Infection in High-Risk Patients: A Prospective Randomized Multicenter Trial

^a Universitätsklinik Würzburg, Klinik für Thorax-, Herz- und Thorakale Gefäbchirurgie, Würzburg, Germany
^b Klinikum Passau, Klinik für Herzchirurgie, Passau, Germany
^c Universitätsklinik Münster, Klinik und Poliklinik für Thorax-, Herz- und Gefäbchirurgie, Münster, Germany
^d Städt. Klinikum München GmbH, Klinikum Bogenhausen, Abteilung für Herzchirurgie, München, Germany
^e Zentralklinik Bad Berka GmbH, Klinik für Herzchirurgie, Bad Berka, Germany
^f Universitätsklinikum Erlangen, Herzchirurgische Klinik, Erlangen, Germany
^g Center of Clinical Trial Würzburg (ZKSW), Würzburg, Germany

Accepted for publication August 1, 2008.

^_* Address correspondence to Dr Schimmer, Universität Würzburg, Klinik und Poliklinik für Thorax-, Herz- und Thorakale Gefäbchirurgie, Oberdürrbacherstrabe 6, Wurzburg, 97080, Germany (Email: schimmer_c{at}klinik.uni-wuerzburg.de).

Background: One factor for the development of sternal wound infection (SWI) is bony instability after sternotomy. This study compares two surgical techniques with respect to the occurrence of SWI in patients with an increased risk.

Methods: In this multicenter study, 815 consecutive patients with an increased risk for SWI were prospectively randomly assigned to a conventional osteosynthesis (transsternal or peristernal wiring; n = 440) or to an osteosynthesis with additional lateral reinforcement (Robicsek; n = 375). Primary endpoints were the rate of sternal dehiscence as well as the occurrence of superficial sternal wound infections and deep sternal wound infections.

Results: Both groups were comparable concerning preoperative and intraoperative variables. The rate of sternal dehiscence, superficial sternal wound infections, and deep sternal wound infections (conventional technique 2.5%, 3.4%, 2.5%; and Robicsek 3.7%, 5.6%, 3.7%) did not differ between the groups. Logistic regression analysis found independent risk factors for the development of sternal dehiscence: body mass indes greater than 30 kg/m² (odds ratio [OR]: 2.9; p = 0.05), New York Heart Association class more than III (OR: 2.4; p = 0.07), impaired renal function (OR: 3.9; p = 0.01), peripheral arterial disease (OR: 3.6; p = 0.001), immunosuppressant state (OR: 3.3; p = 0.001), sternal closure performed by an assistant doctor (OR: 2.5, p = 0.004), postoperative bleeding (OR: 4.2; p = 0.03), transfusion of more than 5 red blood units (OR: 3.7, p = 0.01), reexploration for bleeding (OR: 6.9, p = 0.001), and postoperative delirium (OR: 3.5, p = 0.01). There was an inverse relation between the numbers of wires and DSWI in patients with conventional sternal closure (p = 0.008).

Conclusions: In patients with an increased risk for sternal instability and wound infection after cardiac surgery, sternal reinforcement according to the technique described by Robicsek did not reduce this complication.

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