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Ann Thorac Surg 2008;86:491-495. doi:10.1016/j.athoracsur.2008.03.061
© 2008 The Society of Thoracic Surgeons
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Kenneth K. Liao
Ranjit John
Lyle D. Joyce
Soon J. Park
Richard Bianco
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Right arrow Mechanical Circulatory Assistance
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Original Articles: Adult Cardiac

Mechanical Stress: An Independent Determinant of Early Bioprosthetic Calcification in Humans

Kenneth K. Liao, MDa,*, Xiaohuan Li, MDa, Ranjit John, MDa, Devesh M. Amatya, PhDa, Lyle D. Joyce, MD, PhDa, Soon J. Park, MDb, Richard Bianco, MSa, R. Morton Bolman, III, MDc

a Division of Cardiothoracic Surgery, University of Minnesota, Minneapolis
b Division of Cardiac Surgery, Mayo Clinic, Rochester, Minnesota
c Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, Massachusetts

Accepted for publication March 25, 2008.

* Address correspondence to Dr Liao, Division of Cardiothoracic Surgery, University of Minnesota, MMC 207, 420 Delaware St SE, Minneapolis, MN 55455 (Email: liaox014{at}umn.edu).

Presented at the Poster Session of the Forty-fourth Annual Meeting of The Society of Thoracic Surgeons, San Diego, CA, Jan 29–31, 2007.

Background: Mechanical stress is one of the contributing factors for bioprosthetic calcification. A HeartMate XVE (Thoratec, CA) left ventricular assist device (LVAD) has two identical porcine valves, one for inflow and the other for outflow. The inflow valve endures a higher closing pressure than the outflow valve; thus, an implanted LVAD offers an ideal human model to study the independent effect of stress on calcification.

Methods: Sixty-four pairs of LVAD inflow and outflow valves underwent gross examination, histologic study, and x-ray imaging. X-ray films were converted to digital images, and the calcification area was calculated. The distribution of calcium deposits was documented. The frequency and degree of calcification in both valves were analyzed (paired t test). Calcification of both valves in relationship to the duration of LVAD implantation and to the patient's age was also analyzed (linear regression).

Results: The mean age of patients supported with LVAD was 55 ± 12 years (range, 17 to 77 years). The mean duration of LVAD implantation was 265 ± 151 days (range, 3 to 630 days). Calcification developed more commonly in inflow valves. The calcification area (CA) was larger in the inflow valves (21.6 ± 30.7 mm2) than in the outflow valves (15.1 ± 26.2 mm2, p < 0.05). There was a positive relationship between CA and days of implantation for both valves (inflow CA = 4.96 ± 0.063 days; outflow, CA = 2.39 ± 0.047 days, linear regression; p < 0.05 for both).

Conclusions: Mechanical stress is an independent determinant of early bioprosthetic calcification in humans.






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