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Ann Thorac Surg 2008;86:327-334. doi:10.1016/j.athoracsur.2008.03.038
© 2008 The Society of Thoracic Surgeons
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Dominique Shum-Tim
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Review

Myocardial Regenerative Therapy: Immunologic Basis for the Potential "Universal Donor Cells"

Rony Atoui, MD, MSc, Dominique Shum-Tim, MD, MS, Ray C.J. Chiu, MD, PhD*

Division of Cardiac Surgery, McGill University Health Center, Montreal, Quebec, Canada

* Address correspondence to Dr Chiu, The Montreal General Hospital, MUHC, Suite C9-169, 1650 Cedar Ave, Montreal, Quebec, H3G 1A4, Canada (Email: ray.chiu{at}mcgill.ca).

Stem cell transplantation is a promising approach for improving cardiac function after severe myocardial damage for which use of autologous donor cells have been preferred to avoid immune rejection. Recently however, rodent, porcine, and even human bone marrow stromal cells have been reported to be uniquely immune tolerant, both in the in vitro mixed lymphocyte co-culture studies and in the in vivo allo-transplant and xeno-transplant models. In this review, we explore the current understanding of the underlying immunologic mechanisms, which can facilitate the use of such cells as "universal donor cells" with fascinating therapeutic implications.




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