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Original Articles: Pediatric Cardiac

Hybrid Approach for Hypoplastic Left Heart Syndrome: Intermediate Results After the Learning Curve

^a The Heart Center, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio
^b Division of Cardiothoracic Surgery, The Ohio State University, Columbus, Ohio
^c Division of Pediatric Cardiology, The Ohio State University, Columbus, Ohio

Accepted for publication February 4, 2008.

^_* Address correspondence to Dr Galantowicz, 700 Children's Drive, Columbus, OH 43205 (Email: mark.galantowicz{at}nationwidechildrens.org).

Presented at the Forty-third Annual Meeting of The Society of Thoracic Surgeons, San Diego, CA, Jan 29–31, 2007.

Background: Lessons learned during the development of a novel hybrid approach have resulted in a reliable, reproducible alternative treatment for hypoplastic left heart syndrome (HLHS). Herein we report our results using this hybrid approach in a uniform risk cohort.

Methods: This is a review of prospectively collected data on patients treated for HLHS using a hybrid approach (n = 40) between July 2002 and June 2007. The hybrid approach includes pulmonary artery bands, a ductal stent, and atrial septostomy as a neonate, comprehensive stage 2 procedure resulting in Glenn shunt physiology at six months and Fontan completion at two years.

Results: Forty patients had a hybrid stage 1 with 36 undergoing a comprehensive stage 2 procedure. Fifteen patients have completed the Fontan procedure with 17 pending. Overall survival was 82.5% (33 of 40). The seven deaths included one at stage 1, two between stages 1 and 2, three at stage 2, and one between stages 2 and 3. One patient had successful heart transplantation during the interstage period.

Conclusions: The hybrid approach can yield acceptable intermediate results that are comparable with a traditional Norwood strategy. Potential advantages of the hybrid approach include the avoidance of circulatory arrest and shifting the major surgical stage to later in life. These data provide the platform for a prospective trial comparing these two surgical options to assess whether there is less cumulative impact with the hybrid approach, thereby improving end organ function, quality, and quantity of life.

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