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Case Reports

Treatment of a Nonhealing Saphenous Vein Harvest Graft with Treprostinil Sodium

^a Comprehensive Cardiovascular Care Group, Milwaukee, Wisconsin
^b Infectious Disease Associates, Milwaukee, Wisconsin
^c United Therapeutics Corporation, Research Triangle Park, North Carolina

Accepted for publication November 20, 2007.

^_* Address correspondence to Dr Zwicke, Comprehensive Cardiovascular Care Group, 2801 W. Kinnickinnic River Pkwy, Ste 777, Milwaukee, WI 53215 (Email: dzwicke1{at}yahoo.com).

Impaired healing of saphenous vein harvest sites is a serious but under-recognized complication of coronary artery bypass grafting surgery, particularly in the presence of peripheral arterial disease. We report the use of a continuous subcutaneous infusion of treprostinil sodium, an analog of prostacyclin, to treat a limb-threatening, nonhealing saphenous vein harvest incision site after myocardial revascularization.