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Original Articles: General Thoracic

Diffusing Capacity Predicts Morbidity After Lung Resection in Patients Without Obstructive Lung Disease

Department of Surgery, The University of Chicago, Chicago, Illinois

Accepted for publication December 19, 2007.

^_* Address correspondence to Dr Ferguson, Department of Surgery, The University of Chicago, 5841 S. Maryland Ave MC5035, Chicago, IL 60637 (Email: mferguso{at}surgery.bsd.uchicago.edu).

Presented at the Fifty-fourth Annual Meeting of the Southern Thoracic Surgical Association, Bonita Springs, FL, Nov 7–10, 2007.

Background: Diffusing capacity (DLCO), an independent predictor of morbidity after major lung resection, is not used routinely in preoperative evaluation because of a perceived lack of value in patients with normal spirometry. We evaluated the potential utility of measuring DLCO for assessment of operative risk in lung resection patients with normal spirometry.

Methods: A retrospective review was conducted for patients undergoing lung resection from 1980 through 2006 to identify predictors of postoperative morbidity. Patients were divided into groups with or without chronic obstructive lung disease (COPD), defined as a ratio of forced expiratory volume in the first second to forced vital capacity of less than 0.7 or a ratio of 0.7 or greater, respectively. Analyses for each group identified covariates for three outcomes: operative mortality, pulmonary morbidity, and overall morbidity.

Results: Of 1,046 patients in the database, 1,008 (545 men; mean age, 61.8 ± 0.35 years) had data permitting determination of COPD status: 450 (45%) with COPD, 558 (55%) without COPD. Operations included lobectomy (752; 75%), bilobectomy (83; 8%), and pneumonectomy (173; 17%). Overall mortality, pulmonary morbidity, and overall morbidity incidences were 59 (5.8%), 140 (14.0%), and 311 (31.4%), respectively. Pulmonary morbidity and operative mortality were related to postoperative predicted DLCO, age, and performance status in patients with and without COPD. The postoperative predicted DLCO was the single strongest predictor of pulmonary morbidity and operative mortality in both patient groups. Overall complications were related to postoperative predicted DLCO only in the COPD group.

Conclusions: Diffusing capacity is an important predictor of postoperative morbidity after lung resection even in patients with normal spirometry. Routine measurement of DLCO, regardless of spirometric findings, can help predict risk in candidates for major lung resection.

This article has been cited by other articles:

				M. K. Ferguson, H. A. Gaissert, J. D. Grab, and S. Sheng Pulmonary complications after lung resection in the absence of chronic obstructive pulmonary disease: The predictive role of diffusing capacity J. Thorac. Cardiovasc. Surg., December 1, 2009; 138(6): 1297 - 1302. [Abstract] [Full Text] [PDF]

				A. Charloux, A. Brunelli, C. T. Bolliger, G. Rocco, J.-P. Sculier, G. Varela, M. Licker, M. K. Ferguson, C. Faivre-Finn, R. M. Huber, et al. Lung function evaluation before surgery in lung cancer patients: how are recent advances put into practice? A survey among members of the European Society of Thoracic Surgeons (ESTS) and of the Thoracic Oncology Section of the European Respiratory Society (ERS) Interactive CardioVascular and Thoracic Surgery, December 1, 2009; 9(6): 925 - 931. [Full Text] [PDF]

				R. J. Cerfolio, A. Talati, and A. S. Bryant Changes in pulmonary function tests after neoadjuvant therapy predict postoperative complications. Ann. Thorac. Surg., September 1, 2009; 88(3): 930 - 935. [Abstract] [Full Text] [PDF]

				R. J. Cerfolio and A. S. Bryant Different diffusing capacity of the lung for carbon monoxide as predictors of respiratory morbidity. Ann. Thorac. Surg., August 1, 2009; 88(2): 405 - 410. [Abstract] [Full Text] [PDF]

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