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Ann Thorac Surg 2008;85:525-529. doi:10.1016/j.athoracsur.2007.09.040
© 2008 The Society of Thoracic Surgeons
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Right arrow Coronary disease

Original Articles: Cardiovascular

Serial Quantitative Coronary Analyses for the Evaluation of One-Year Change in Saphenous Vein Grafts

Nobuaki Suzuki, MDa,*, Ken Kozuma, MD, PhDa, Yasunari Ueno, MDa, Kensuke Nagaoka, MDa, Hiroyuki Kyono, MDa, Shuichi Ishikawa, MDa, Hidenori Watanabe, MD, PhDa, Naoyuki Yokoyama, MD, PhDa, Satoshi Takeshita, MD, PhDb, Takaaki Isshiki, MD, PhDa

a Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
b Department of Medicine, National Cardiovascular Center, Osaka, Japan

Accepted for publication September 20, 2007.

* Address correspondence to Dr Suzuki, Department of Medicine, Teikyo University School of Medicine, 2-11-1 Kaga Itabashi-ku, Tokyo, 173-8605, Japan (Email: nsuzu{at}bronze.ocn.ne.jp).

Background: A paucity of data exists with respect to changes in whole saphenous vein grafts (SVGs) despite accelerated atherosclerosis within grafted saphenous vein conduits. In the present study, we evaluated the one-year change in SVGs by means of quantitative coronary analysis.

Methods: This study enrolled consecutive 52 patients with 109 SVGs, who underwent coronary artery bypass graft surgery successfully. A follow-up study was performed in 33 patients with 65 SVGs after one year because 16 SVGs were obstructed (baseline, 8; follow-up period, 8), and 15 patients with 28 SVGs dropped out within one year.

Results: Both minimal and mean lumen diameters decreased significantly (3.17 ± 0.64 mm vs 2.41 ± 0.57 mm, p < 0.001; 3.70 ± 0.69 mm vs 2.92 ± 0.70 mm, p < 0.001; respectively). Graft length also decreased significantly (107.1 ± 25.8 vs 100.6 ± 25.2 mm, p < 0.001). The graft shortening rate (graft shortening length/baseline graft length x 100) was greater than 5% in 33 vessels (51%) and greater than 10% in 23 vessels (35%). Coronary risk factors (smoking, diabetes mellitus, hypertension, dyslipidemia) did not reveal significant relationship with late loss of minimal and mean lumen diameters.

Conclusions: The present study showed a considerable and uniform lumen loss of SVGs after one year, irrespective of coronary risk factors. Graft length shortening was seen more than elongation.






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Copyright © 2008 by The Society of Thoracic Surgeons.