ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Ann Thorac Surg 2007;84:1467-1473. doi:10.1016/j.athoracsur.2007.06.023
© 2007 The Society of Thoracic Surgeons
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Mark F. Newman
Shahar Bar-Yosef
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Puskas, F.
Right arrow Articles by Bar-Yosef, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Puskas, F.
Right arrow Articles by Bar-Yosef, S.
Related Collections
Right arrow Cerebral protection
Right arrow Coronary disease

Original Articles: Cardiovascular

Intraoperative Hyperglycemia and Cognitive Decline After CABG

Ferenc Puskas, MD, PhD, Hilary P. Grocott, MD, FRCPC, William D. White, MPH, Joseph P. Mathew, MD, Mark F. Newman, MD, Shahar Bar-Yosef, MD*

Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina

Accepted for publication June 6, 2007.

* Address correspondence to Dr Bar-Yosef, Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710. (Email: baryo001{at}mc.duke.edu).

Background: Neurocognitive dysfunction (NCD) continues to occur in a significant number of patients after cardiac procedures. The factors influencing its incidence and severity are not completely known. We hypothesized that hyperglycemia, which is known to exacerbate other forms of cerebral injury, may exacerbate NCD after cardiac operations.

Methods: A total of 525 patients having on-pump coronary artery bypass graft (CABG) procedures underwent cognitive testing at baseline and 6 weeks postoperatively. Multivariable linear regression was used to determine the relationship between NCD and intraoperative hyperglycemia (glucose ≥200 mg/dL). Diabetic and nondiabetic patients were analyzed separately to eliminate a possible confounding effects between diabetes and hyperglycemia.

Results: In the nondiabetic patients, even after controlling for age, years of education, and baseline cognitive function, hyperglycemia was associated with a decrease in cognitive function at 6 weeks (p = 0.0351). Hyperglycemia had no effect on cognitive function in diabetic patients, however.

Conclusions: These findings suggest that in nondiabetic patients undergoing CABG operations, intraoperative hyperglycemia is associated with an increased risk of NCD.




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
A. M. Grigore, C. F. Murray, H. Ramakrishna, and G. Djaiani
A Core Review of Temperature Regimens and Neuroprotection During Cardiopulmonary Bypass: Does Rewarming Rate Matter?
Anesth. Analg., December 1, 2009; 109(6): 1741 - 1751.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
J. Huffmyer and J. Raphael
Physiology and Pharmacology of Myocardial Preconditioning and Postconditioning
Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2009; 13(1): 5 - 18.
[Abstract] [PDF]

Home page
 CirculationHome page
A. Polito, R. R. Thiagarajan, P. C. Laussen, K. Gauvreau, M. S.D. Agus, M. A. Scheurer, F. A. Pigula, and J. M. Costello
Association Between Intraoperative and Early Postoperative Glucose Levels and Adverse Outcomes After Complex Congenital Heart Surgery
Circulation, November 25, 2008; 118(22): 2235 - 2242.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
K Svennevig, T. Hoel, A. Thiara, S. Kolset, A Castelheim, T. Mollnes, F Brosstad, E Fosse, and J. Svennevig
Syndecan-1 plasma levels during coronary artery bypass surgery with and without cardiopulmonary bypass
Perfusion, May 1, 2008; 23(3): 165 - 171.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2007 by The Society of Thoracic Surgeons.