HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Carlos Simón Federico González-Aragoneses Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Simón, C. Search for Related Content PubMed PubMed Citation Articles by Simón, C. Related Collections Lung - cancer Related Article

Ann Thorac Surg 2007;84:952-958
© 2007 The Society of Thoracic Surgeons

---

Original Articles: General Thoracic

The Side of Pneumonectomy Influences Long-Term Survival in Stage I and II Non-Small Cell Lung Cancer

^a Thoracic Surgery Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain
^b Anatomical Pathology Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain

Accepted for publication April 23, 2007.

^_* Address correspondence to Dr Simón, Cirugía Torácica, Hospital Gregorio Marañón, C/ Dr. Esquerdo 46, Madrid, 28007, Spain (Email: cm_simon{at}telefonica.net).

Background: The impact of pneumonectomy as an independent factor on long-term survival after lung resection for centrally or locally advanced non-small cell lung cancer (NSCLC) remains controversial. The aim of this paper is to study the impact of pneumonectomy, and the influence of side of surgery, on long-term survival in patients with pathologic stage I and II NSCLC.

Methods: A retrospective review of a prospective multi-institutional database of patients operated on for lung cancer was undertaken. In all, 1,475 patients with pathologic stage I or II NSCLC were studied (421 underwent pneumonectomy; 1,054 had a lobectomy/bilobectomy). Survival and impact of side of surgery for pneumonectomy and lesser resection groups were analyzed and compared using the Kaplan-Meier method and the Cox proportional hazards model.

Results: Median survival was worse after pneumonectomy than after less extensive resections for patients overall (33 versus 57 months) and for those with stage I NSCLC (38 versus 70 months); however, median survival was better after pneumonectomy for stage II left tumors (55 versus 19 months). Pneumonectomy was an independent adverse determinant of survival for both stage I right tumors (p < 0.001) and stage I left tumors (p < 0.001), but was associated with improved survival for stage II left tumors (p = 0.009).

Conclusions: Pneumonectomy was found to be an independent determinant of survival in patients with stage I and II NSCLC, but results differed for right- and left-sided tumors. Further studies of survival comparing pneumonectomy with lesser resections should differentiate between right and left procedures.

Related Article

Invited commentary

Robert James Cerfolio
Ann. Thorac. Surg. 2007 84: 958. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				E. J. Veen, M. L.G. Janssen-Heijnen, E. D. Ritchie, B. Biesma, M. P.H. van den Bogart, and R. Jan Bolhuis Pneumonectomy for bronchogenic carcinoma: analysis of factors predicting short- and long-term outcome Interactive CardioVascular and Thoracic Surgery, August 1, 2009; 9(2): 260 - 264. [Abstract] [Full Text] [PDF]

				R. J. Cerfolio Invited commentary Ann. Thorac. Surg., September 1, 2007; 84(3): 958 - 958. [Full Text] [PDF]