ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Discussion
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Alessandro Parolari
Francesco Alamanni
Marco Agrifoglio
Paolo Biglioli
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Parolari, A.
Right arrow Articles by Tremoli, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parolari, A.
Right arrow Articles by Tremoli, E.
Related Collections
Right arrow Coronary disease

Ann Thorac Surg 2007;84:823-828
© 2007 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Systemic Inflammation After On-Pump and Off-Pump Coronary Bypass Surgery: A One-Month Follow-Up

Alessandro Parolari, MD, PhDa,*, Marina Camera, Biol Sci, PhDa,b, Francesco Alamanni, MDa, Moreno Naliato, MDa, Gian Luca Polvani, MDa, Marco Agrifoglio, MD, PhDa, Marta Brambilla, Biol Scia,b, Carla Biancardi, Techa, Luciana Mussoni, PhDb, Paolo Biglioli, MDa, Elena Tremoli, PhDa,b

a Department of Cardiac Surgery, Centro Cardiologico Monzino I.R.C.C.S, University of Milan, Italy
b Department of Pharmacological Sciences, University of Milan, Italy

Accepted for publication April 16, 2007.

* Address correspondence to Dr Parolari, Department of Cardiac Surgery, University of Milan, Centro Cardiologico - Fondazione Monzino IRCCS, Via Parea, 4, Milan, 20138, Italy (Email: alessandro.parolari{at}cardiologicomonzino.it).

Background: This study sought to assess inflammation activation in the follow-up (up to one month) of coronary bypass surgery performed both on- (CABG) and off-pump (OPCAB).

Methods: Thirty patients, candidates for coronary surgery, were randomized to undergo CABG (n = 16) or OPCAB (n = 14). Blood samples were collected before the intervention, after protamine administration, and 4, 8, and 30 days after surgery.

Results: Plasma tumor necrosis factor-alpha (TNF-{alpha}) and interleukin-6 (IL-6) levels significantly increased with respect to baseline from protamine administration up to eight postoperative days, whereas high-sensitivity C-reactive protein (hs-CRP) and fibrinogen increased after surgery up to eight postoperative days in both groups. On the other hand, neutrophil elastase levels were higher than baseline from protamine administration up to four postoperative days in CABG, and at the time point eight days after surgery in OPCAB. The only significant differences between CABG and OPCAB in inflammatory markers occurred intraoperatively, after protamine administration, when TNF-{alpha} and elastase levels were higher in CABG, whereas no differences were detected between CABG and OPCAB at any postoperative time point. Postoperative increases in fibrinogen and hs-CRP were positively correlated with increases in IL-6, but not with postoperative changes in TNF-{alpha} both in CABG and OPCAB.

Conclusions: After coronary bypass surgery, there is a protracted postoperative activation of inflammation persisting several days after surgery; this postoperative activation is not affected by the surgical strategy (on-pump or off-pump).




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
G. Huang, C. Luo, X. Gu, Z. Wu, Z. Wang, Z. Du, C. Hu, and L. Tang
Mechanical Strain Induces Expression of C-Reactive Protein in Human Blood Vessels
J. Pharmacol. Exp. Ther., July 1, 2009; 330(1): 206 - 211.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. E. Cho, J. K. Shim, Y. S. Choi, D. H. Kim, S. W. Hong, and Y. L. Kwak
Effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery
Br. J. Anaesth., January 1, 2009; 102(1): 23 - 28.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
D. Paparella, G. Scrascia, A. Galeone, M. Coviello, G. Cappabianca, M. T. Venneri, B. Favoino, M. Quaranta, L. de Luca Tupputi Schinosa, and T. E. Warkentin
Formation of anti-platelet factor 4/heparin antibodies after cardiac surgery: influence of perioperative platelet activation, the inflammatory response, and histocompatibility leukocyte antigen status.
J. Thorac. Cardiovasc. Surg., December 1, 2008; 136(6): 1456 - 1463.
[Abstract] [Full Text] [PDF]

Home page
 Nutr Clin PractHome page
R. A. DiMaria-Ghalili
Nutrition Risk Factors in Older Coronary Artery Bypass Graft Patients
Nutr Clin Pract, October 1, 2008; 23(5): 494 - 500.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Castellheim, T. N. Hoel, V. Videm, E. Fosse, A. Pharo, J. L. Svennevig, A. E. Fiane, and T. E. Mollnes
Biomarker Profile in Off-Pump and On-Pump Coronary Artery Bypass Grafting Surgery in Low-Risk Patients
Ann. Thorac. Surg., June 1, 2008; 85(6): 1994 - 2002.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
K Svennevig, T. Hoel, A. Thiara, S. Kolset, A Castelheim, T. Mollnes, F Brosstad, E Fosse, and J. Svennevig
Syndecan-1 plasma levels during coronary artery bypass surgery with and without cardiopulmonary bypass
Perfusion, May 1, 2008; 23(3): 165 - 171.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2007 by The Society of Thoracic Surgeons.