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Tiziano Colombo
Andrea Garatti
Ettore Vitali
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Right arrow Transplantation - heart

Ann Thorac Surg 2007;84:522-527
© 2007 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Long-Term Follow-Up of Simultaneous Heart and Kidney Transplantation With Single Donor Allografts: Report of Nine Cases

Giuseppe Bruschi, MDa,*, Ghil Busnach, MDb, Tiziano Colombo, MDa, Loredana Radaelli, MDb, Giovanna Pedrazzini, MDa, Andrea Garatti, MDa, Cosimo V. Sansalone, MDc, Maria Frigerio, MDa, Ettore Vitali, MDa

a Department of Cardiology and Cardiac Surgery "A. De Gasperis,", Niguarda Ca’ Granda Hospital, Milan, Italy
b Nephrology Unit, Niguarda Ca’ Granda Hospital, Milan, Italy
c Kidney-Pancreas Transplantation Unit, Niguarda Ca’ Granda Hospital, Milan, Italy

Accepted for publication April 2, 2007.

* Address correspondence to Dr Bruschi, "A De Gasperis" Cardiology and Cardiac Surgery Department, Niguarda Ca’ Granda Hospital, Piazza Ospedale Maggiore, 3, Milan, 20162, Italy (Email: giuseppe.bruschi{at}fastwebnet.it).

Background: Combined heart-kidney transplantation is an accepted therapeutic option for patients with end-stage heart disease associated with severely impaired renal function. We report our single-institutional experience with this combined procedure and long-term follow-up.

Methods: Between April 1989 and August 2006, 9 patients underwent combined simultaneous heart-kidney transplantation at our center. Seven patients were male (mean age, 45.2 ± 10.12 years); 7 patients were on dialysis at transplantation. Whenever possible, donors were selected on the basis of ABO identity, weight (ratio ≥ 0.9), on-site or short-distance procurement, young age, low inotropic support, and normal renal function.

Results: Mean ischemic time was 132.2 ± 57.0 minutes for the cardiac allograft and 6.0 ± 1.0 hours for the kidney. Surgical procedure was uneventful in all patients. One patient died in the intensive care unit 41 days after transplantation. Three patients died during follow-up, 1 of lung neoplasm after 6 years, 1 of cerebral stroke after 34 months, and 1 of infection and multiorgan failure after 148 months. The mortality rates led to an overall actuarial survival of 88.9% ± 10.4% at 1 year, 77.8% ± 13.6% at 5 years, and 64.8% ± 16.5% at 10 years. Seven patients lived beyond 5 years, 4 beyond 10 years, and the patient who has longest survival is patient no. 1, with 17 years of follow-up. One patient lost kidney function after 113 months.

Conclusions: In selected patients, with coexisting end-stage cardiac and renal failure, combined heart-kidney transplantation with allograft from the same donor proved to have satisfactory short- and long-term results, with a low incidence of both cardiac and renal allograft rejection.






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