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Ann Thorac Surg 2007;84:288-290
© 2007 The Society of Thoracic Surgeons


Case Reports

Unusual Pathogenesis of Spontaneous Pneumothorax Secondary to Wegener’s Granulomatosis

Erica Storelli, MDa, Christian Casali, MDa, Pamela Natali, MDa, Giulio Rossi, MDb, Uliano Morandi, MDa,*

a Department of General Surgery and Surgical Specialties, Division of Thoracic Surgery, University of Modena and Reggio Emilia, Modena, Italy
b Department of Diagnostic and Laboratory Services and Legal Medicine, Section of Pathologic Anatomy, University of Modena and Reggio Emilia, Modena, Italy

Accepted for publication January 22, 2007.

* Address correspondence to Dr Morandi, Division of Thoracic Surgery, Policlinico di Modena, Largo del Pozzo 71, Modena, 41100, Italy (Email: uliano.morandi{at}unimore.it).

Spontaneous pneumothorax represents a rare and potentially severe complication of Wegener’s granulomatosis. A 31-year-old man with Wegener’s granulomatosis on immunosuppressive therapy was admitted for a right massive spontaneous pneumothorax. After chest drainage he presented with a prolonged air leak that required a surgical treatment. Histologic findings did not reveal any necrotizing granulomatous vasculitis, but only subpleural fibrous tissue. We hypothesize that pneumothorax could be related to the subpleural fibrous retraction induced by immunosuppressive therapy.







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