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Ann Thorac Surg 2007;84:269-270
© 2007 The Society of Thoracic Surgeons

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Case Reports

Daptomycin for Eradication of a Systemic Infection With a Methicillin-Resistant-Staphylococcus Aureus in a Biventricular Assist Device Recipient

^a Department of Anesthesiology, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany
^b Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany, Munich, Germany

Accepted for publication February 1, 2007.

^_* Address correspondence to Dr Florian Weis, Department of Anesthesiology, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, 81377, Germany (Email: florian.weis{at}med.uni-muenchen.de).

The rate of infection in patients who require ventricular assist devices is estimated at more than 35%. Infections with multi-resistant organisms such as methicillin-resistant Staphylococcus aureus in ventricular assist device recipients are often difficult to treat and present a high mortality rate. Daptomycin is a new cyclic lipopeptide antibiotic, useful in gram-positive organisms resistant to standard treatment. We report a case of a 65-year-old man suffering from a dilatative cardiomyopathy and concomitant MRSA infection who received a biventricular assist device. The patient had MRSA sepsis develop resistant to conventional therapy, which was successfully treated with daptomycin.

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				D. P. Levine Clinical experience with daptomycin: bacteraemia and endocarditis J. Antimicrob. Chemother., November 1, 2008; 62(suppl_3): iii35 - iii39. [Abstract] [Full Text] [PDF]