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Ann Thorac Surg 2007;83:1547-1549
© 2007 The Society of Thoracic Surgeons

Case Reports

Postoperative Coagulopathy in a Pediatric Patient After Exposure to Bovine Topical Thrombin

Sheri S. Crow, MDa, Vita V. Sullivan, MDd, Agnes E. Aysola, MDb, Nigel S. Key, MB, FRCPc, Paul Harker-Murray, MD, PhDa, John E. Foker, MD, PhDd, Marie E. Steiner, MD, MSa,*

a Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
b Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota
c Department of Medicine, University of Minnesota, Minneapolis, Minnesota
d Department of Surgery, University of Minnesota, Minneapolis, Minnesota

Accepted for publication October 30, 2006.

* Address correspondence to Dr Steiner, Pediatric Hematology/Oncology and Pediatric Pulmonary/Critical Care, MMC 484, University of Minnesota, Minneapolis, MN 55455 (Email: stein083{at}umn.edu).

Severe postoperative coagulopathy developed in a child with congenital heart disease due to a factor V inhibitor from repetitive exposure to bovine topical thrombin. This case report alerts pediatric providers to consider these inhibitors when postoperative coagulopathy occurs. Potential treatment options are reviewed.




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D. L. Diesen and J. H. Lawson
Bovine Thrombin: History, Use, and Risk in the Surgical Patient
Vascular, April 2, 2008; 16(suppl_1): S29 - S36.
[Abstract] [Full Text] [PDF]


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