ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Jean-François Obadia
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Greffe, G.
Right arrow Articles by Obadia, J.-F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Greffe, G.
Right arrow Articles by Obadia, J.-F.
Related Collections
Right arrow Valve disease

Ann Thorac Surg 2007;83:1541-1543
© 2007 The Society of Thoracic Surgeons

Case Reports

Valvular Heart Disease Associated With Fenfluramine Detected 7 Years After Discontinuation of Treatment

Guillaume Greffe, MDa, Lara Chalabreysse, MDb, Carine Mouly-Bertin, MDc, Pierre Lantelme, MD, PhDd, Françoise Thivolet, MDb, Gilles Aulagner, MDc, Jean-François Obadia, MD, PhDa,*

a Department of Cardiothoracic Surgery, Louis Pradel Hospital, Lyon, France
b Department of Cytopathology, Louis Pradel Hospital, Lyon, France
c Department of Pharmacy, Louis Pradel Hospital, Lyon, France
d Department of Cardiology, Croix-Rousse Hospital, Lyon, France

Accepted for publication November 9, 2006.

* Address correspondence to Dr Obadia, Hôpital Cardiothoracique Louis Pradel, 28 Avenue du Doyen Lépine, Lyon-Bron, 69677 France (Email: jf.o{at}chu-lyon.fr).

We report the case of a patient referred to us for mitral and aortic valvular disease with a rheumatic appearance. The unusual macroscopic appearance on valve resection was not compatible with a rheumatic cause. A detailed review of this patient’s clinical history (ie, a history of treatment with fenfluramine) suggested an iatrogenic cause, which was confirmed by histology. For the first time, a case of valvular heart disease that deteriorated was discovered 7 years after treatment with fenfluramine, whereas this iatrogenic disease classically resolves after discontinuation of treatment. This case illustrates the need for continuing heart valve surveillance of patients who have used these anorectics.




This article has been cited by other articles:


Home page
 Eur J EchocardiogrHome page
S. Droogmans, D. Kerkhove, B. Cosyns, and G. Van Camp
Role of echocardiography in toxic heart valvulopathy
Eur J Echocardiogr, June 1, 2009; 10(4): 467 - 476.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2007 by The Society of Thoracic Surgeons.