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Motonobu Nishimura
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Ann Thorac Surg 2007;83:661-662
© 2007 The Society of Thoracic Surgeons

Case Reports

Cardiac Resurrection After Bone-Marrow-Derived Mononuclear Cell Transplantation During Left Ventricular Assist Device Support

Satoshi Gojo, MD, PhDa,*, Shunei Kyo, MD, PhDa,b, Shigeyuki Nishimura, MD, PhDc, Nobuyuki Komiyama, MD, PhDc, Nobutaka Kawai, MD, PhDd, Masami Bessho, MD, PhDd, Hiroshige Sato, MD, PhDa, Toshihisa Asakura, MD, PhDa, Motonobu Nishimura, MD, PhDb, Kenji Ikebuchi, MD, PhDe

a Department of Cardiovascular Surgery, Saitama Medical Center, Saitama, Japan
b Department of Cardiovascular Surgery, Saitama Medical School, Saitama, Japan
c Department of Cardiology, Saitama Medical School, Saitama, Japan
d Department of Hematology, Saitama Medical School, Saitama, Japan
e Department of Transfusion and Cell Therapy, Saitama Medical School, Saitama, Japan

Accepted for publication June 23, 2006.

* Address correspondence to Dr Gojo, Department of Cardiovascular Surgery, Saitama Medical Center 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan. (Email: satoshi{at}saitama-med.ac.jp).

We describe a novel therapy of mononuclear cell transplantation combined with a left ventricular assist device (LVAD) for severe ischemic heart failure. Significant myocardial recovery by the LVAD rarely occurs in the severely failing heart. We undertook successful mononuclear cell transplantation in a patient who sustained an acute myocardial infarction that had resulted in the LVAD therapy. The heart regained good function after cell transplantation, and the LVAD was explanted 6 weeks later. These results suggest that this novel therapy could be an alternative to cardiac transplantation for severe ischemic heart failure.






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