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Hideki Oshima
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Ann Thorac Surg 2007;83:648-654
© 2007 The Society of Thoracic Surgeons

New Technology

In Vivo Evaluation of a Porous, Elastic, Biodegradable Patch for Reconstructive Cardiac Procedures

Kazuro L. Fujimoto, MDa,b, Jianjun Guan, PhDa,b, Hideki Oshima, MDa, Tetsuro Sakai, MD, PhDb,c, William R. Wagner, PhDa,b,d,*

a Department of Surgery, McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania
b Department of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania
c Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania
d Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania

Accepted for publication June 19, 2006.

* Address correspondence to Dr Wagner, 100 Technology Dr, Pittsburgh, PA 15219. (Email: wagnerwr{at}upmc.edu).

PURPOSE: Several synthetic materials have been used for cardiac reconstruction in patients with complex congenital heart defects. These materials are not viable, do not grow with children, and may necessitate reoperation. We report here on the cardiac implantation of a recently developed, degradable porous material designed to facilitate cellular ingrowth during the healing process.

DESCRIPTION: An elastomeric, biodegradable polyester urethane urea (PEUU) was processed into circular scaffolds and used to replace a surgical defect in the right ventricular outflow tract of adult rats. Control rats were implanted with expanded polytetrafluoroethylene. Histologic evaluation was performed at 4, 8, and 12 weeks postsurgery.

EVALUATION: All animals survived the surgery. Both PEUU and expanded polytetrafluoroethylene were encapsulated with fibrous tissue and had complete endothelialization on the endocardial surface with no aneurysm formation or thrombus noted. With PEUU patching, fibroblast ingrowth occurred at 4 weeks, increasing with time. In contrast, expanded polytetrafluoroethylene patches exhibited no ingrowth and elicited local inflammation that moderated with time.

CONCLUSIONS: The PEUU patch demonstrated suitable mechanical properties and biocompatible characteristics in the right ventricular outflow tract replacement model, permitting cellular integration and endocardial endothelialization with minimal inflammation. Future application of this material as a cardiovascular scaffold seems promising.


Related Article

Invited commentary
Pascal Maria Dohmen
Ann. Thorac. Surg. 2007 83: 654. [Extract] [Full Text] [PDF]



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Invited commentary
Ann. Thorac. Surg., February 1, 2007; 83(2): 654 - 654.
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