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Ann Thorac Surg 2007;83:578-585
© 2007 The Society of Thoracic Surgeons

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Original Articles: Cardiovascular

Cell Salvage Alters the Systemic Inflammatory Response After Off-Pump Coronary Artery Bypass Grafting Surgery

^a Department of Clinical Anaesthesia, Royal Group of Hospitals Trust, Belfast, Ireland
^b Department of Cardiothoracic Surgery, Royal Group of Hospitals Trust, Belfast, Ireland
^c Department of Anaesthetics and Intensive Care, Queens University, Belfast, Ireland
^d Department of Immunobiology, Queens University, Belfast, Ireland
^e Department of Clinical Chemistry, Queens University, Belfast, Ireland

Accepted for publication September 11, 2006.

^_* Address correspondence to Dr Allen, Department of Clinical Anaesthesia, Royal Group of Hospitals Trust, Grosvenor Rd, Belfast, N. Ireland, United Kingdom BT12 6BA (Email: stephen.allen{at}royalhospitals.n-i.nhs.uk).

BACKGROUND: Retransfused cardiotomy suction blood contains elevated inflammatory markers and is a bypass independent source of inflammatory mediators. We hypothesized that, during off-pump coronary artery bypass (OPCAB) grafting surgery, avoiding retransfusion of unwashed cardiotomy suction blood would beneficially alter both urinary and plasma cytokine concentrations and be renoprotective.

METHODS: Thirty-seven OPCAB surgery patients were randomly allocated to control (retransfusion of unwashed shed blood) and treatment (retransfusion of washed shed blood or discarding of unwashed blood) groups. Over 72 hours we measured plasma (tumor necrosis factor- [TNF-], interleukin-8, interleukin-6, interleukin-10, TNF soluble receptor-2, and interleukin-1 receptor antagonist) and urinary TNF soluble receptor-2 and interleukin-1 receptor antagonist and markers of renal injury and dysfunction (N-acetyl ß D glucosaminidase and ₁-microglobulin).

RESULTS: We demonstrated elevated proinflammatory cytokines in cardiotomy suction blood, which were effectively eliminated by cell salvage. After retransfusion, in comparison with controls, the treatment group had reduced plasma TNF soluble receptor-2. As compared with controls, treatment group patients also demonstrated significantly reduced levels of the urinary anti-inflammatory cytokine TNF soluble receptor-2. There were no between group differences in markers of renal injury or dysfunction.

CONCLUSIONS: We have demonstrated that the management of shed mediastinal blood alters perioperative, systemic, plasma and urinary cytokine homeostasis at OPCAB surgery but does not impact on subclinical renal injury or dysfunction in this low risk group of patients.

This article has been cited by other articles:

				M. Boodhwani, H. J. Nathan, T. G. Mesana, F. D. Rubens, and Cardiotomy Investigators Effects of shed mediastinal blood on cardiovascular and pulmonary function: a randomized, double-blind study. Ann. Thorac. Surg., October 1, 2008; 86(4): 1167 - 1173. [Abstract] [Full Text] [PDF]